The inter-relationships of the neural basis of rumination and inhibitory control: neuroimaging-based meta-analyses

Abstract Rumination, as a clinical manifestation and pathogenic factor of depression, has long been the focus psychological research regarding its causes ameliorating approaches. Behavioral studies have shown that rumination is related to inhibitory control deficits, which provides ideas for reducing it. However, neural relationship between them not clearly discussed. In this study, we first used multi-level kernel density analysis conduct two meta-analyses published functional magnetic resonance imaging studies: one was comprising 17 with 180 foci, other 205 3791 foci. Conjunction then performed explore common brain regions further decode through Neurosynth confirm cognitive specificity. Results showed mainly default mode network (DMN), while associated frontoparietal (FPN). addition, activation areas were concentrated in bilateral precuneus, right superior frontal gyrus, median cingulate, paracingulate gyri, left triangular part inferior gyrus (IFG). Decoding results also revealed they involved inhibition, memory retrieval, self-related processes. Our findings support can be explained neurologically by an antagonistic DMN FPN. sum, may via inhibiting task-unrelated attention controlling processing. This will help us understand predict from perspective reduce behavioral training or application neuromodulation techniques regions.